发明名称 |
PHARMACEUTICAL SOLID DISPERSIONS |
摘要 |
A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
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申请公布号 |
US2013029965(A1) |
申请公布日期 |
2013.01.31 |
申请号 |
US201213610350 |
申请日期 |
2012.09.11 |
申请人 |
BEND RESEARCH, INC.;BABCOCK WALTER C.;FRIESEN DWAYNE T.;NIGHTINGALE JAMES A. S.;SHANKER RAVI M. |
发明人 |
BABCOCK WALTER C.;FRIESEN DWAYNE T.;NIGHTINGALE JAMES A. S.;SHANKER RAVI M. |
分类号 |
A61K31/44;A61K47/38;A61K9/14;A61K9/16;A61K31/404;A61K31/455;A61K47/30;A61P25/24 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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