发明名称 |
Suppressors of RNA Silencing as Modulators of miRNA Levels |
摘要 |
The invention describes use of RNA silencing suppressors or interactors of the suppressors to bring the expression of microRNAs involved in any disease, including malignant neoplasia, back to its normal level. More specifically the present invention provides a method to regulate many miRNAs at the same time. Most of the suppressors according to this invention are coded by plant viruses that unexpectedly can affect RNA silencing and modulate miRNA expression levels in mammalian cells. Also suppressors of endogenous origin are described as able to modulate miRNA expression levels.
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申请公布号 |
US2013029417(A1) |
申请公布日期 |
2013.01.31 |
申请号 |
US201113578703 |
申请日期 |
2011.02.18 |
申请人 |
AS VAHIUURINGUTE TEHNOLOOGIA ARENDUSKESKUS;TALLINN UNIVERSITY OF TECHNOLOGY;SARMIENTO GUERIN MARIA CECILIA;KARBLANE KAIRI;PATA ILLAR;TRUVE ERKKI;PATA PILLE |
发明人 |
SARMIENTO GUERIN MARIA CECILIA;KARBLANE KAIRI;PATA ILLAR;TRUVE ERKKI;PATA PILLE |
分类号 |
C12N5/071 |
主分类号 |
C12N5/071 |
代理机构 |
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主权项 |
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地址 |
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