CRYSTALLINE FORMS OF A BIPHENYL COMPOUND

摘要

THE INVENTION PROVIDES CRYSTALLINE FORMS OF BIPHENYL-2-YLCARBAMIC ACID 1-(2-{[4-(4- CARBARMOYLPIPERIDIN- 1 -YLTMETHYL) BENZOYL]METHYLAMINO} ETHYL) PIPERIDIN-4-YL ESTER, AND PHARMACEUTICALLY ACCEPTABLE SOLVATES THEREOF. THE CRYSTA LLINE FORM CAN BE A FREEBASE, OR A SALT SUCH AS A DIPHOSPHATE, MONOSULFATE OR DIOXALATE SALT. THE INVENTION ALSO PROVIDES PHARMACEUTICAL COMPOSITIONS COMPRISING THESE CRYSTALLINE COMPOUNDS OR PREPARED USING THESE COMPOUNDS; PROCESSES AND INTERMEDIATES FOR PREPARING THE CRYSTALLINE COMPOUNDS, AND METHODS OF USING THESE COMPOUNDS TO TREAT A PULMONARY DISORDER.