PHARMACEUTICAL COMBINATION COMPRISING AN INDOLINONE DERIVATIVE AND A CHEMOTHERAPEUTIC AGENT, OPTIONALLY ADAPTED FOR CO-TREATMENT WITH RADIOTHERAPY OR RADIOIMMUNOTHERAPY IN THE FORM OF COMBINED PREPARATION FOR SIMULTANEOUS, SEPARATE OR SEQUENTIAL USE

摘要

The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.