| 发明名称 |
Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs |
| 摘要 |
Compounds of the formula: <IMAGE> (I) are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.
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| 申请公布号 |
US5254682(A) |
申请公布日期 |
1993.10.19 |
| 申请号 |
US19910714114 |
申请日期 |
1991.06.11 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
DHANOA, DALJIT S.;PATCHETT, ARTHUR A.;GREENLEE, WILLIAM J.;PARSONS, WILLIAM H.;HALGREN, THOMAS A.;WEBER, ANN E.;YANG, LIHU |
| 分类号 |
A61K31/335;A61K31/357;A61K31/39;A61K31/395;A61K31/40;A61K31/435;A61K31/44;A61K31/4427;A61K31/443;A61K31/445;A61K31/495;A61K31/535;A61K38/00;A61P5/38;A61P9/00;A61P9/12;A61P27/02;A61P27/06;A61P31/12;A61P43/00;C07D225/02;C07D245/02;C07D267/00;C07D273/00;C07D273/01;C07D273/02;C07D281/00;C07D285/00;C07D291/02;C07D313/00;C07D321/00;C07D323/00;C07D327/00;C07D327/02;C07D401/12;C07D403/12;C07D405/12;C07D411/12;C07D413/12;C07D417/12;C07D419/12;C07D453/02;C07D487/04;C07F9/6527;C07F9/6558;C07F9/6561;C07K5/02;C07K5/065;C07K5/078;C07K5/097;(IPC1-7):C07D225/00 |
主分类号 |
A61K31/335 |
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