发明名称 |
Methods for identifying nucleic acid ligands |
摘要 |
The SELEX (Systematic Evolution of Ligands by EXponential Enrichment) method is disclosed for the identification of nucleic acid ligands. A candidate mixture of single stranded nucleic acids having regions of randomized sequence is contacted with a target compound and those nucleic acids having an increased affinity to the target are partitioned from the remainder of the candidate mixture. The partitioned nucleic acids are amplified to yield a ligand enriched mixture.
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申请公布号 |
US5270163(A) |
申请公布日期 |
1993.12.14 |
申请号 |
US19920931473 |
申请日期 |
1992.08.17 |
申请人 |
UNIVERSITY RESEARCH CORPORATION |
发明人 |
GOLD, LARRY;TUERK, CRAIG |
分类号 |
C07B61/00;C07H19/06;C07H19/10;C07H21/00;C07K14/00;C12N9/12;C12N15/10;C12Q1/37;C12Q1/68;C12Q1/70;F02B75/02;G01N33/531;G01N33/532;G01N33/535;G01N33/569;G01N33/68;G01N33/76;(IPC1-7):C12Q1/68;C12P19/34 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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