METHODS FOR SCREENING CANDIDATE AGENTS FOR MODULATING PRORENIN AND RENIN, ASSAYS FOR DETECTING PRORENIN, AND ANTIBODIES USED THEREIN

摘要

The present invention relates to antibodies that bind to prorenin. In particular, the invention relates to monoclonal antibodies that bind to prorenin and inhibit the activation of prorenin. The antibodies of the invention are useful for screening for candidate agents that inhibit the activation of prorenin and candidate agents the modulate the activity of renin. The antibodies are also useful as diagnostics and for treating disease states.