RECEPTORS TARGETING INFLAMMATION AND DRUG CARRIERS FOR TREATMENT OF INFLAMMATORY DISEASES

摘要

PURPOSE: An inflammation-targeting receptor and a drug delivery system for treating inflammatory diseases are provided to ensure excellent inflammation-targeting effect and to deliver a drug into an inflammatory lesion. CONSTITUTION: An pharmaceutical composition for treating inflammatory diseases or immune-modulatory treatment contains a fusion protein as an active ingredient, which contains an inflammatory inhibitor or an immune booster which is linked to a fragment containing an extracellular region of IL21R(interlukin 21 receptor), VcamI(vascular cell adhesion molecule 1), IL2RB(interleukin-2 receptor subunit beta), IL3RA(interleukin 3 receptor, alpha), IL13RA1(interleukin 13 receptor, alpha 1), or CRLF1(cytokine receptor like factor 1). The fragment containing an extracellular region IL21R contains a polypeptide with an amino acid sequence of sequence number 4.