| 发明名称 |
METHODS OF INCREASING EFFICIENCY OF VECTOR PENETRATION OF TARGET TISSUE |
| 摘要 |
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP. |
| 申请公布号 |
EP2550021(A2) |
申请公布日期 |
2013.01.30 |
| 申请号 |
EP20110709425 |
申请日期 |
2011.03.22 |
| 申请人 |
ASSOCIATION INSTITUT DE MYOLOGIE;GENETHON;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
VOIT, THOMAS;GARCIA, LUIS;DENARD, JEROME;SVINARTCHOUK, FEDOR |
| 分类号 |
A61K48/00;C12N15/864 |
主分类号 |
A61K48/00 |
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