| 摘要 |
<p>AbstractMICROBIAL CONVERSION OF OILS AND FATTY ACIDS TO HIGH-VALUE CHEMICALSMicroorganisms for the production of high-value chemicals from free fatty acids are provided. The microorganisms comprise genetic mutations that alter fatty acid metabolism. The genetic mutations include a mutation or deletion of a fadR gene in which the fadR enzyme activity is partially or substantially eliminated and a mutation in an atoC gene that provides overexpression of the microorganism's ato operon. Methods of using the microorganisms to produce high-value chemicals are also provided. The high-value chemicals include ethanol, methyl acetate, succinate, gamma-butyrolactone, 1,4-butanediol, acetone, isopropanol, butyrate, butanol, mevalonate, propionate, ethanolamine and 1,2-propanediol.(Figure 1)</p> |
