发明名称 |
System and method to correct out of phase errors in DNA sequencing data by use of a recursive algorithm |
摘要 |
An embodiment of a method for correcting an error associated with phasic synchrony of sequence data generated from a population of template molecules is described that comprises the steps of detecting signals generated in response to nucleotide species introduced during a sequencing reaction; generating an observed value for the signal detected from each of the nucleotide species; defining positive incorporation values and negative incorporation values from the observed values using a carry forward value and an incomplete extension value; and revising the carry forward value and the incomplete extension value using a noise value that is derived from observed values associated with the negative incorporation values.
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申请公布号 |
US8364417(B2) |
申请公布日期 |
2013.01.29 |
申请号 |
US201113043063 |
申请日期 |
2011.03.08 |
申请人 |
454 LIFE SCIENCES CORPORATION;CHEN YI-JU;WONG CHIU TAI ANDREW |
发明人 |
CHEN YI-JU;WONG CHIU TAI ANDREW |
分类号 |
G06F19/00;G06F15/00 |
主分类号 |
G06F19/00 |
代理机构 |
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代理人 |
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地址 |
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