发明名称 |
Recombinant BCG tuberculosis vaccine designed to elicit immune responses to mycobacterium tuberculosis in all physiological stages of infection and disease |
摘要 |
A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
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申请公布号 |
US8361482(B2) |
申请公布日期 |
2013.01.29 |
申请号 |
US20090618037 |
申请日期 |
2009.11.13 |
申请人 |
AERAS GLOBAL TB VACCINE FOUNDATION;SHAFFERMAN AVIGDOR;ZVI ANAT;ARIEL NAOMI;FULKERSON JOHN;SUN ROAGGAI;CHANG ROSEMARY;SADOFF JERALD C. |
发明人 |
SHAFFERMAN AVIGDOR;ZVI ANAT;ARIEL NAOMI;FULKERSON JOHN;SUN ROAGGAI;CHANG ROSEMARY;SADOFF JERALD C. |
分类号 |
A61K39/04;A61K39/00;A61K48/00 |
主分类号 |
A61K39/04 |
代理机构 |
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