发明名称 Arylsulfonamide based matrix metalloprotease inhibitors
摘要 The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
申请公布号 US8362063(B2) 申请公布日期 2013.01.29
申请号 US201213481983 申请日期 2012.05.29
申请人 NOVARTIS AG;TOMMASI RUBEN ALBERTO;SHULTZ MICHAEL;MCQUIRE LESLIE WIGHTON;RIGOLLIER PASCAL;ROGEL OLIVIER;EHRHARDT CLAUS 发明人 TOMMASI RUBEN ALBERTO;SHULTZ MICHAEL;MCQUIRE LESLIE WIGHTON;RIGOLLIER PASCAL;ROGEL OLIVIER;EHRHARDT CLAUS
分类号 A61K31/416;C07D231/54 主分类号 A61K31/416
代理机构 代理人
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