发明名称 |
O-linked glycosylation of peptides |
摘要 |
The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response.
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申请公布号 |
US8361961(B2) |
申请公布日期 |
2013.01.29 |
申请号 |
US20050585385 |
申请日期 |
2005.01.10 |
申请人 |
BIOGENERIX AG;DEFREES SHAWN;ZOPF DAVID A.;WANG ZHI-GUANG;CLAUSEN HENRIK |
发明人 |
DEFREES SHAWN;ZOPF DAVID A.;WANG ZHI-GUANG;CLAUSEN HENRIK |
分类号 |
A61K38/14;A61K38/18;A61K38/19;C07K1/107;C07K9/00;C07K14/535 |
主分类号 |
A61K38/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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