ARYL- AND HETEROARYL-SUBSTITUTED PYRAZOL DERIVATIVES AND PREPARATION THEREOF

摘要

PURPOSE: A method for preparing a novel aryl- and heteroaryl-substituted pyrazole derivative and a pharmaceutical composition containing the derivative are provided to be used as a melanoma proliferation inhibitor. CONSTITUTION: An aryl- and heteroaryl-substituted pyrazole derivative is denoted by chemical formula I. A method for proliferating the derivative or a pharmaceutically acceptable salt thereof comprises a step of reacting 3-phenyl-4-pyridinyl pyrazole derivative of chemical formula III with phenyl chloroformate to prepare a compound of chemical formula IV. A pharmaceutical composition for preventing or treating melanoma contains the derivative or pharmaceutically acceptable salt and a pharmaceutically acceptable carrier.