| 发明名称 |
Azetidines as MEK inhibitors for the treatment of proliferative diseases |
| 摘要 |
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
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| 申请公布号 |
US8362002(B2) |
申请公布日期 |
2013.01.29 |
| 申请号 |
US201113048832 |
申请日期 |
2011.03.15 |
| 申请人 |
EXELIXIS, INC.;AAY NAING;ANAND NEEL KUMAR;BLAZEY CHARLES M.;BOWLES OWEN JOSEPH;BUSSENIUS JOERG;COSTANZO SIMONA;CURTIS JEFFRY KIMO;DEFINA STEVEN CHARLES;DUBENKO LARISA;JOSHI ANAGHA ABHIJIT;KENNEDY ABIGAIL R.;KIM ANGIE INYOUNG;KOLTUN ELENA S.;MANALO JEAN-CLAIRE LIMUN;PETO CSABA J.;RICE KENNETH D.;TSANG TSZE H. |
发明人 |
AAY NAING;ANAND NEEL KUMAR;BLAZEY CHARLES M.;BOWLES OWEN JOSEPH;BUSSENIUS JOERG;COSTANZO SIMONA;CURTIS JEFFRY KIMO;DEFINA STEVEN CHARLES;DUBENKO LARISA;JOSHI ANAGHA ABHIJIT;KENNEDY ABIGAIL R.;KIM ANGIE INYOUNG;KOLTUN ELENA S.;MANALO JEAN-CLAIRE LIMUN;PETO CSABA J.;RICE KENNETH D.;TSANG TSZE H. |
| 分类号 |
A61K31/397;A61K31/4178;A61K31/4523;A61K31/50;A61K31/505 |
主分类号 |
A61K31/397 |
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