发明名称 |
COMBINED CHEMOTHERAPY AND IMMUNOTHERAPY |
摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to biotechnology and medicine, more specifically to the use of EGFRvIII in a combination with temozolomide, and may be used for treating a tumour in an individual. A method of treating the tumour in the individual provides introducing into the individual an amount of temozolomide effectively inducing lymphopenia; monitoring of white blood cell count after introducing temozolomide; and introducing into the individual an effective amount of the EGFRvIII peptide for white blood cell count recovery in a point of the least white blood cell count. Introducing the EGFRvIII peptide into the individual may be combined with introducing the effective amount of GM-CSF as an adjuvant.EFFECT: invention enables the combined chemotherapy and immunotherapy without downing the immunotherapeutic effects with temozolomide-induced lymphopenia being able to intensify action of a peptide vaccine.19 cl, 6 ex |
申请公布号 |
RU2473560(C2) |
申请公布日期 |
2013.01.27 |
申请号 |
RU20080120665 |
申请日期 |
2006.11.02 |
申请人 |
D'JUK JUNIVERSITI;JUNIVERSITI OF TEKHAS M.D.ANDERSON KEHNSER SENTER |
发明人 |
SEHMPSON DZHON KH.;BIGNER DARELL D.;KHAJMBERGER EHMI;MITCHELL DUEHJN |
分类号 |
C07K14/47;A61K39/00;A61P35/00;C07K14/71 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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