ISONICOTINAMIDE OREXIN RECEPTOR ANTAGONISTS

摘要

592544 Disclosed are isonicotinamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. Also disclosed are pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved. Examples of the compounds are: N-(3,4-dimethoxybenzyl)-2,5-bis(3,5-dimethylphenyl) isonicotinamide; N -(3 ,4-dimethoxybenzyl)-6-(3 ,5-dimethylphenyl)-3,3 -bipyridine-4-carboxamide and N-(3,4-dimethoxybenzyl)-2-(3,5-dimethylphenyl)-5-(1-methy1-1H-pyrazol-4-yl)isonicotinamide.