发明名称 |
METHOD FOR MANUFACTURING A PHARMACEUTICAL COMPOSITION IN THE FORM OF EXTENDED-RELEASE TABLETS CONTAINING PIRFENIDONE AND USE THEREOF IN THE REGRESSION OF CHRONIC RENAL INSUFFICIENCY, BREAST CAPSULAR CONTRACTURE AND HEPATIC FIBROSIS IN HUMANS |
摘要 |
The present invention relates to a method for manufacturing a pharmaceutical composition in the form of extended-release tablets that include from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), such that the drug containing same is bioavailable during an extended period of 12 hours from the administration thereof. This optimizes the anti-fibrotic and anti-inflammatory action of the Pirfenidone. Additionally, the present invention offers advantages and better therapeutic effectiveness over other pharmaceutical forms of Pirfenidone for oral administration and the therapeutic use thereof in the regression of chronic secondary renal insufficiency to primary glomerulosclerosis; it shows greater activity in the decrease and/or regression of the toxic effects on the breast capsular contracture observed after surgical implantation of breast implants in humans and exercises a significant anti-TNF-a and anti-TGF-ß? action in the treatment of hepatic fibrosis. |
申请公布号 |
WO2013012307(A1) |
申请公布日期 |
2013.01.24 |
申请号 |
WO2012MX00067 |
申请日期 |
2012.07.13 |
申请人 |
CELL THERAPY AND TECHONOLOGY S.A. DE C.V.;ARMENDARIZ BORUNDA , JUAN;MAGANA CASTRO, JOSE AUGUSTIN ROGELIO;CERVANTES GUADARRAMA, JORGE |
发明人 |
ARMENDARIZ BORUNDA , JUAN;MAGANA CASTRO, JOSE AUGUSTIN ROGELIO;CERVANTES GUADARRAMA, JORGE |
分类号 |
A61K9/16;A61K9/20;A61K31/4412 |
主分类号 |
A61K9/16 |
代理机构 |
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地址 |
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