WOUND HEALING COMPOSITIONS AND ASSOCIATED METHODS

摘要

The present disclosure provides a composition including an aqueous solution comprising about 1% to about 50% weight/volume poloxamer having the general formula HO(C2H4O)a(C3H6O)b(C2H4O)aH, wherein a ranges from 12-106 and b ranges from 20-70, and a substrate. The present disclosure provides a method of attaching a substrate to a tissue by applying a substrate to a tissue and applying an aqueous solution comprising a poloxamer to the tissue in an amount sufficient for the poloxamer to hold the substrate to the tissue. The present disclosure also provides a method of facilitating wound closure by applying an original substrate to a wound. The present disclosure also provides a method of holding a wound closed or holding a graft to a wound by applying the above aqueous solution or a powder.