DENSITY-BASED METHOD OF COMPARING IMAGES AND DETECTION OF MORPHOLOGICAL CHANGES USING THE METHOD THEREOF

摘要

The present invention relates to a method of processing data for comparing at least two images using data processing means. A first sample of coordinate values (X1,...,Xn1) is extracted (100) from at least one first image (Im1) and a second sample of coordinate values (Y1,...,Yn2) is extracted (100) from at least one second image (Im2). A normal score value (Z) is then computed (200), with the processing means, based on a density test statistic function (T) applied on the first and second samples of coordinate values, wherein this density test statistic function has an asymptotic distribution, and a p-value, derived from the computed normal score value (Z), is compared (400) with a predetermined level of significance (a) in order to determine a similarity between the two images. Such a method can be used for example for determining the influence of a compound on a biological structure, monitoring a drug treatment comprising one or more specific treatment compound(s), assessing the cytotoxicity of a predetermined compound on a biological structure, determining cellular morphology changes due to modifications in the expression level of cellular constituents, determining the influence of a infection by pathogens or detecting morphological changes in a biological structure over time.