| 摘要 |
The present invention relates to a process for the preparation of estra-1,3,5(10)- trien-3, 15a, 16a, 17ß-tetraol (estetrol), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-l,3,5(10), 16-tetraene, wherein A is a protecting group and B is -Si(R2)3. The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10), 15-tetraen-17-one, wherein A is a protecting group, via said silyl enol ether derivative. |
| 申请人 |
PANTARHEI BIOSCIENCE B.V.;PLATTEEUW, JOHANNES JAN;COELINGH BENNINK, HERMAN JAN TIJMEN;DAMEN, FRANCISCUS WILHELMUS PETRUS;VAN VLIET, MICHIEL CHRISTIAN ALEXANDER |
发明人 |
PLATTEEUW, JOHANNES JAN;COELINGH BENNINK, HERMAN JAN TIJMEN;DAMEN, FRANCISCUS WILHELMUS PETRUS;VAN VLIET, MICHIEL CHRISTIAN ALEXANDER |
