| 摘要 |
1 a-hydroxy vitamin D2 (doxercalciferol) of exceptionally high purity and stability is prepared by a process involving chromatographically purifying 1 α-hydroxyvitamin D2 monoacetate, chemically removing the acetate protectant group from the purified product to form 1 α-hydroxyvitamin D2, and precipitating the 1 a-hydroxyvitamin D2 so formed from a mixed organic solvent consisting essentially of at least one C1-C6 dialkyl ether or C1-C6 alkyl ester, and at least one C5-C12 hydrocarbon.
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