AGENT CONTAINING B-RING-SUBSTITUTED FLAVONOID DERIVATIVES FOR TREATING ARTHRITIS

摘要

The present invention relates to flavonoid derivatives expressed by the following general formula (I), to a composition containing the pharmaceutically acceptable salts thereof as an active ingredient, and to the use of the flavonoid derivatives. More particularly, the flavonoid derivatives expressed by the following general formula (I), or the pharmaceutically acceptable salts thereof, may exhibit an activity of inhibiting the decomposition of cartilage constituents, an activity of inhibiting the decomposition of ECM, and an activity of inhibiting the expression of MMP-13, and may exhibit a superior activity of inhibiting the deterioration of joints in a chronic-arthritis animal test. Therefore, the flavonoid derivatives or the pharmaceutically acceptable salts thereof may be used in a pharmaceutical composition and a functional health food that is useful for preventing and treating arthritis.