发明名称 |
INTRANASAL ADMINISTRATION OF AGENTS WITH PRO-INFLAMMATORY ACTIVITY FOR THE THERAPY OF NEUROLOGICAL DISORDERS |
摘要 |
The invention concerns a product consisting of distilled water or of an aqueous solution hypotonic or substantially isotonic with respect to blood plasma or, less preferably, hypertonic with respect to blood plasma, to be administered on the nasal mucosa according to a specific operation mode in order to cause an inflammation of an irritative kind, for use in a treatment of stimulation of the endogenous production of inflammatory mediators, in the therapy and prevention of neurological disorders, in particular of degenerative disorders of the central and peripheral nervous system. The inflammatory mediators the endogenous production of which is stimulated comprise NGF, neurotrophin-3, neurotrophin-4, serotonin, substance P, heparin, ECF-A. |
申请公布号 |
WO2013011536(A1) |
申请公布日期 |
2013.01.24 |
申请号 |
WO2012IT00227 |
申请日期 |
2012.07.20 |
申请人 |
SALVINELLI, FABRIZIO;SALVINELLI, BEATRICE;SALVINELLI, EMANUELE;D'ERAMO, ALESSANDRA |
发明人 |
SALVINELLI, FABRIZIO;SALVINELLI, BEATRICE;SALVINELLI, EMANUELE;D'ERAMO, ALESSANDRA |
分类号 |
A61K31/7004;A61K33/00;A61K33/04;A61K33/14 |
主分类号 |
A61K31/7004 |
代理机构 |
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代理人 |
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地址 |
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