摘要 |
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
GURNEY, AUSTIN, L.;SATO, AARON, KEN;AXELROD, FUMIKO, TAKADA;HOEY, TIMOTHY, CHARLES;SATYAL, SANJEEV, H.;MITRA, SATYAJIT, SUJIT, KUMAR |