| 摘要 |
Administration .beta.-lactam compounds, including of inhibitors of certain bacterial peptidases have been found to provide significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced cognition believed to be mediated by inhibition of neurogenic NAALADase and related enzyme activity. .beta.-Lactam antibiotics and .beta.-lactamase inhibitors have been found to exhibit potent NAALADase inhibition, and those compounds with blood brain barrier transport are effective inhibitors of neurogenic NAALADase with significant neuro-therapeutic effects. .beta.-Lactam compounds are useful for treatment of numerous disease states associated with glutamate abnormalities. Therapeutic methods for using such compounds and their pharmaceutical formulations are described. Specifically, the invention relates to use of a .beta.-lactam compound selected from clavulanic acid, moxalactam, a pharmaceutically acceptable salt thereof, or an active ester form thereof, for use in the treatment of a sexual disorder.
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