SYSTEM FOR IDENTIFYING AND ANALYZING EXPRESSION OF ARE-CONTAINING GENES

摘要

Adenylate-uridylate-rich (ARE) elements present in the 3' untranslated region (UTR) of gene and mRNA sequences are disclosed. THE ARE motif comprises a sequence encompassed by: SEQ ID NO: 1 or 2, with further limitations. Computational methods of identifying genes or coding sequences in a database which comprise ARE elements are disclosed. The computational methods can be used for gene discovery, and sequence analysis. Methods of identifying, isolating and amplyfying ARE-element-associated polynucleotides using PCR, RT-PCR, hybridization, etc. are disclosed. PCR primers, oligonucleotide arrays, polynucleotide libraries, computer programs, and computer systems relating to ARE elements are disclosed.