Aldehyde tags, uses thereof in site-specific protein modification
摘要
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
申请公布号
EP2548967(A2)
申请公布日期
2013.01.23
申请号
EP20120176853
申请日期
2007.09.19
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人
CARRICO, ISAAC S.;CARLSON, BRIAN L.;WU, PENG;BERTOZZI, CAROLYN