| 摘要 |
<p>A tricyclic indole-2-carboxylic acid derivative represented by the formula 1: <CHEM> wherein X represents alkyl, halogen or cyano; R<1> represents hydrogen, or a protecting group of carboxyl group; W represents hydrogen, -CO2R<3i>, -CONR<3i>R<4i>, -A-CO2R<3i> or -A-CONR<3i>R<4i>, wherein -A- represents alkylene and R<3i> and R<4i> independently represent hydrogen, alkyl, aryl or substituted aryl, or a pharmaceutically acceptable salt thereof, these compounds are selective antagonists of glycine binding site of the NMDA receptor.</p> |
