<p>The present application relates to monoclonal antibodies and antigen-binding portions thereof, that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The application also relates to isolated heavy and light chain immunoglobulins derived from the anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present application also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.</p>
申请公布号
EP2548890(A1)
申请公布日期
2013.01.23
申请号
EP20120189220
申请日期
2008.12.30
申请人
BAXTER INTERNATIONAL INC;BAXTER HEALTHCARE S.A.;DYAX CORPORATION
发明人
KERSCHBAUMER, RANDOLF;SCHEIFLINGER, FRIEDRICH;RIEGER, MANFRED;THIELE, MICHAEL;MUDDE, C. GEERT;MUELLBERG, JUERGEN;HOET, RENE