发明名称 |
LYOPHILIZED ANTI-FUNGAL COMPOSITION |
摘要 |
<p>A lyophilized anti-fungal composition comprises (A) caspofungin, or a pharmaceutically acceptable salt thereof, in an effective amount; (B) one or more non-reducing sugars having a glass transition temperature Tg(s) of at least about 90° C.; and (C) an acetate buffer in an amount effective to provide a pH in a range of from about 5 to about 7; wherein the weight ratio of the one or more non-reducing sugars to caspofungin is in a range of from about 1.1:1 to about 10:1; the composition has a moisture content of about 0.8 wt. % or less; and the composition has a glass transition temperature Tg(c) of at least about 55° C. The lyophilized composition has good storage stability at temperatures up to and including room temperature. The composition can be reconstituted for use in preventing or treating fungal infections.</p> |
申请公布号 |
EP2170362(A4) |
申请公布日期 |
2013.01.23 |
申请号 |
EP20080768730 |
申请日期 |
2008.06.23 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
MITTAL, SACHIN;JAHANSOUZ, HOSSAIN;SOTTHIVIRAT, SUTTHILUG |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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