发明名称 |
Reprogramming a cell by inducing a pluripotent gene through RNA interference |
摘要 |
The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method for inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the expression of a gene that codes for a protein involved in transcriptional repression. In yet another embodiment, the invention relates to a reprogrammed cell or an enriched population of reprogrammed cells that can have characteristics of an ES-like cell, which can be re- or trans-differentiated into a differentiated cell type.
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申请公布号 |
US8357666(B2) |
申请公布日期 |
2013.01.22 |
申请号 |
US20090384667 |
申请日期 |
2009.04.07 |
申请人 |
NUPOTENTIAL, INC.;EILERTSEN KENNETH J.;POWER RACHEL A.;RIM JONG S. |
发明人 |
EILERTSEN KENNETH J.;POWER RACHEL A.;RIM JONG S. |
分类号 |
A61K48/00;C07H21/02;C07H21/04;C12N15/85;C12Q1/70 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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