发明名称 |
METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MATRIX MINERALIZATION DISORDERS. |
摘要 |
<p>The present invention provides methods, compositions, and kits for the treatment of matrix mineralization disorders such as hypophosphatasia. In particular, the present invention provides polypeptides having a soluble alkaline phosphatase fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to patients, e.g., subcutaneously, to treat hypophosphatasia using enzyme replacement therapy. The invention also features nucleic acids encoding such polypeptides and the use of the nucleic acids for treating matrix mineralization disorders.</p> |
申请公布号 |
MX2012012643(A) |
申请公布日期 |
2013.01.22 |
申请号 |
MX20120012643 |
申请日期 |
2011.04.29 |
申请人 |
ALEXION PHARMA INTERNATIONAL SARL.* |
发明人 |
PHILIPPE CRINE;PIERRE LEONARD |
分类号 |
A61K47/48;A61K31/7088;A61K38/17;A61K38/46;A61K48/00;A61P19/08;C12N9/16;C12N15/55;C12N15/867 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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