发明名称 |
METHODS FOR DETERMINING CD8+ T-CELL EPITOPES |
摘要 |
The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention provides modified epitopes suitable for use in prophylactic and/or therapeutic vaccines. In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In particular, the present invention provides means to identify CD8+ T-cell epitopes in HPV strains such as HPV 16 and HPV 18. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
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申请公布号 |
CA2536735(C) |
申请公布日期 |
2013.01.22 |
申请号 |
CA20042536735 |
申请日期 |
2004.08.23 |
申请人 |
GENENCOR INTERNATIONAL, INC. |
发明人 |
HARDING, FIONA A.;MUCHA, JEANETTE MARIE |
分类号 |
C12Q1/68;A61K;A61K38/00;C07H21/04;C07K;C07K14/01;C07K14/74;C12N7/00;C12P21/04;G01N33/50;G01N33/53;G01N33/567;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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