RETINOIC ACID DERIVATIVE, PROCESS FOR PREPARING THE SAME, AND COSMETIC COMPOSITION COMPRISING THE SAME

摘要

PURPOSE: A retinoic acid derivative is provided to have low cytotoxicity, and a collagen synthetic activity, thereby improving wrinkle-reducing effect of a cosmetic composition. CONSTITUTION: A manufacturing method of retinoic acid derivative indicated in chemical formula 1 comprises: a step of synthesizing -Gly-Arg-Glu-Pro by reacting Fmoc-amino acid onto an aminomethyl polystyrene or 2- chlorotrityl chloride polystyrene resin in which a rink amide is accepted under the presence of a coupling agent, and removing Fmoc by treating the result by 20% piperidine/NMP; a step of combining retinoic acid to the -Gly-Arg-Glu-Pro; a step of treating the result by 25% trifluoroacetic acid and dichloromethane to separate the compound indicated in chemical formula 1 from the solid resin. In chemical formula 1, R is -Gly-Arg-Glu-Pro-NH2.