摘要 |
An antibody or antigen-binding fragment thereof, which binds human IL-6 receptor (hIL-6R) with a K D of 500 pM or less, as measured by surface plasmon resonance. In preferred embodiments, the antibody comprising a light chain variable region (LCVR) comprising SEQ ID NO: 13, 15 and 17 as respectively light chain CDR1, CDR2 and CDR3, and a heavy chain variable region (HCVR) comprising SEQ ID NO: 5, 7 and 9 as respectively heavy chain CDR1, CDR2 and CDR3. |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
STEVENS, SEAN;HUANG, TAMMY T;MARTIN, JOEL H;FAIRHURST, JEANETTE L;RAFIQUE, ASHIQUE;POBURSKY, KEVIN J;PAPADOPOULOS, NICHOLAS J;FANDL, JAMES P;CHEN, GANG;KAROW, MARGARET;SMITH, ERIC |