| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salts thereof:where: each of R, R, R, Ris independently selected from a group consisting of a hydrogen atom, a halogen atom, an aryl, a Cheteroaryl having 1-3 heteroatoms in the ring which are selected from O, S and N, -OR, -NRR, and -NRCOR, where said aryl or Cheteroaryl, having 1-3 heteroatoms in the ring selected from O, S and N, is unsubstituted or additionally substituted with one or more groups selected from a group consisting of alkyl, alkoxyl and halogen, each of Rand Ris independently selected from a group consisting of a hydrogen atom or an alkyl, where said alkyl is unsubstituted or additionally substituted with one or more groups selected from a group consisting of an aryl, haloaryl, hydroxyl and alkoxyl. The invention also relates to a pharmaceutical composition which inhibits protein kinase and contains a compound of formula I, a method of producing the compound of formula I, use of said compounds to produce a medicinal agent for treating disorders associated with protein kinase, and a method of modulating catalytic activity of protein kinase.EFFECT: improved method.10 cl, 24 ex |
