| 发明名称 |
A-BETA BINDING POLYPEPTIDES |
| 摘要 |
The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
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| 申请公布号 |
US2013017209(A1) |
申请公布日期 |
2013.01.17 |
| 申请号 |
US201213617248 |
申请日期 |
2012.09.14 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;PARK JOHN E.;DORNER-CIOSSEK CORNELIA;HOERER STEFAN;KUSSMAUL LOTHAR;LENTER MARTIN;ZIMMERMANN KATHARINA;BESTE GERALD;LAEREMANS TOON;MERCHIERS PASCAL;VERCAMMEN JO |
发明人 |
PARK JOHN E.;DORNER-CIOSSEK CORNELIA;HOERER STEFAN;KUSSMAUL LOTHAR;LENTER MARTIN;ZIMMERMANN KATHARINA;BESTE GERALD;LAEREMANS TOON;MERCHIERS PASCAL;VERCAMMEN JO |
| 分类号 |
A61K39/395;A61P25/00;A61P25/22;A61P25/28;A61P27/06;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12N15/63 |
主分类号 |
A61K39/395 |
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