摘要 |
Provided is a method for treating ALS in a subject, comprising administering to the subject a therapeutically effective amount of riluzole and a therapeutically effective amount of CK-2017357. Also provided are methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) in a subject, methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) between two or more subjects, methods of decreasing the total daily dose of riluzole in a subject, methods of increasing the half-life of riluzole in a subject, methods for decreasing the frequency of riluzole dosing in the subject, and methods for reducing the incidence and/or severity of adverse events in a subject treated with riluzole. |
申请人 |
CYTOKINETICS, INC.;CEDARBAUM, JESSE;MAO, JOHN;MALIK, FADY;WOLFF, ANDREW A. |
发明人 |
CEDARBAUM, JESSE;MAO, JOHN;MALIK, FADY;WOLFF, ANDREW A. |