发明名称 |
Nucleic acids encoding anti-IL-6 antibodies of defined epitopic specificity |
摘要 |
The invention relates to nucleic acids encoding antibody or antibody fragments that specifically binds to an epitope on an intact human IL-6 polypeptide, which epitope when ascertained by epitopic mapping includes one or more residues comprised in each of the following IL-6 fragments (i) a fragment consisting of amino acid residues 37-51 of human Il-6, (ii) a fragment consisting of amino acid residues 70-84 of human Il-6, (iii) a fragment consisting of amino acid residues 169-183 of human Il-6, (iv) a fragment consisting of amino acid residues 31-45 of human Il-6 and (v) a fragment consisting of amino acid residues 58-72 of human IL-6.
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申请公布号 |
US2013017575(A1) |
申请公布日期 |
2013.01.17 |
申请号 |
US201113298407 |
申请日期 |
2011.11.17 |
申请人 |
GARCIA-MARTINEZ LEON;JENSEN ANNE ELISABETH CARVALHO;OLSON KATIE;DUTZAR BEN;OJALA ETHAN;KOVACEVICH BRIAN;LATHAM JOHN;SMITH JEFFREY T.L. |
发明人 |
GARCIA-MARTINEZ LEON;JENSEN ANNE ELISABETH CARVALHO;OLSON KATIE;DUTZAR BEN;OJALA ETHAN;KOVACEVICH BRIAN;LATHAM JOHN;SMITH JEFFREY T.L. |
分类号 |
C12N15/13;C12N1/19;C12N1/21;C12N5/10;C12N7/01;C12N15/62;C12N15/63;C12P21/02 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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