| 发明名称 |
MODULATOR OF ATP-BINDING CASSETTE TRANSPORTER |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide: modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"); compositions thereof; and methods therewith. <P>SOLUTION: A 4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods are useful for modulating ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter-mediated diseases using such modulators. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2013010800(A) |
申请公布日期 |
2013.01.17 |
| 申请号 |
JP20120229668 |
申请日期 |
2012.10.17 |
| 申请人 |
VERTEX PHARMACEUTICALS INC |
发明人 |
HADIDA RUAH SARAH S;HAZLEWOOD ANNA R;GROOTENHUIS PETER D J;SINGH ASHVANI K;CLEVELAND THOMAS;VAN GOOR FREDRICK F |
| 分类号 |
C07D239/42;A61K31/505;A61K31/506;A61K31/5377;A61K31/541;A61K31/55;A61P1/12;A61P3/06;A61P5/06;A61P5/18;A61P7/00;A61P7/02;A61P9/14;A61P11/00;A61P13/02;A61P13/12;A61P19/08;A61P21/00;A61P21/02;A61P25/00;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P35/00;A61P43/00;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/04;C07D405/12;C07D409/04;C07D491/113 |
主分类号 |
C07D239/42 |
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