| 摘要 |
Novel peptides are disclosed that may be used as inhibitors of amyloidogenesis, as suppressors of amyloid toxicity, and as therapeutic agents for amyloid-associated diseases such as Alzheimer's disease, Parkinson's Disease, Creutzfeldt-Jakob Disease, Huntington's Disease, and Type II Diabetes. These new beta-strand mimics (beta-sheet "blockers"), containing C<SUP>alpha,alpha</SUP>-disubstituted amino acids, specifically interact with and block the development of the beta-sheet structure of the developing fibrils of amyloid diseases, such as Alzheimer's disease amyloid beta-peptide (Abeta). We have discovered that oligomerization of beta-sheet structures, including those implicated in amyloid-associated diseases, may be inhibited or even reversed by the presence of extended peptide structures that have only one edge available for hydrogen bonding. Without a second edge that is also available for hydrogen bonding, the extension of a developing beta-sheet is blocked by binding to the novel peptides.
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