| 发明名称 |
PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES |
| 摘要 |
The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
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| 申请公布号 |
US2013017598(A1) |
申请公布日期 |
2013.01.17 |
| 申请号 |
US201213354223 |
申请日期 |
2012.01.19 |
| 申请人 |
GENENTECH, INC.;KAO YUNG-HSIANG;LAIRD MICHAEL W.;SCHMIDT MELODY TREXLER;WONG RITA L.;HEWITT DANIEL P. |
发明人 |
KAO YUNG-HSIANG;LAIRD MICHAEL W.;SCHMIDT MELODY TREXLER;WONG RITA L.;HEWITT DANIEL P. |
| 分类号 |
C12N5/10;C12N1/21 |
主分类号 |
C12N5/10 |
| 代理机构 |
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