发明名称 |
NEUROPROTECTIVE PEPTIES THAT INHBIT INTERACTION BETWEEN PALMITOYL ACYL TRANSFERASE ZINC- FINGER DHHC TYPE CONTAINING 17 (ZD17) AND C-JUN N-TERMINAL KINASE (JNK) |
摘要 |
Isolated polypeptides are disclosed herein, the isolated polypeptides comprising at least 90% identity to any one of: SEQ ID NO:1; SEQ ID NO:2; or SEQ ID NO:3, wherein the isolated polypeptide inhibits an interaction between palmitoyl acyl transferase zinc-finger DHHC type containing 17 (z D17) and c-jun N-terminal kinase (JNK). The polypeptides may be conjugated to a delivery and targeting moiety, such as the cell-membrane transduction domain of the HIV-1 Tat protein. There are also provioded methods for treating a disease associated with cytotoxicity or excitotoxicity. |
申请公布号 |
WO2013006978(A1) |
申请公布日期 |
2013.01.17 |
申请号 |
WO2012CA50483 |
申请日期 |
2012.07.12 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA;CYNADER, MAX S.;YANG, GUANG |
发明人 |
CYNADER, MAX S.;YANG, GUANG |
分类号 |
C12N9/10;A61K38/17;A61K47/48;A61P25/28;C07K7/06;C07K7/08;C07K14/16;C07K19/00;C12N9/12 |
主分类号 |
C12N9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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