NOVEL SDF-1-BASED GLYCOSAMINOGLYCAN ANTAGONIST AND METHODS OF USING SAME

摘要

The present invention relates to novel SDF-1 mutant polypeptides with increased GAG binding affinity and reduced GPCR activity compared to wild type SDF-1 protein wherein said SDF-1 polypeptide is modified in a structure-conserving way by replacing glutamine at position 60 by a basic or electron donating amino acid and by replacing at least one additional amino acid at position 29, 39, 49, 67 and/or 68 according to the numbering of SEQ ID NO 1 by at least one basic and/or electron donating amino acid and wherein at least one amino acid of the first 1 to 10 amino acids of the N-terminal region of the wild type SDF-1 polypeptide is modified by addition, deletion and/or replacement of at least one amino acid and methods for producing these mutants and to their use for preparing medicaments for the treatment of cancer.