发明名称 |
Methods for selectively inhibiting Janus tyrosine kinase 3 (Jak3) |
摘要 |
Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.
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申请公布号 |
US7365096(B2) |
申请公布日期 |
2008.04.29 |
申请号 |
US20030731769 |
申请日期 |
2003.12.09 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
KIRKEN ROBERT A.;KAHAN BARRY D.;STEPKOWSKI STANISLAW M.;PRIEBE WALDEMAR;FOKT IZABELA;KOSINSKI SZYMON |
分类号 |
A61K31/21;A61K8/73;A61K31/12;A61K31/13;A61K31/335;C07C225/12;G01N33/50 |
主分类号 |
A61K31/21 |
代理机构 |
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代理人 |
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地址 |
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