发明名称 |
METHOD FOR INCREASING THE EFFICIENCY OF DOUBLE-STRAND BREAK-INDUCED MUTAGENSSIS |
摘要 |
The present invention relates to a method for increasing double-strand-break induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering, including therapeutic applications and cell line engineering. More specifically, the present invention concerns the combined use of TALEN or meganucleases with TREX2, especially under the form of single-chain proteins. |
申请公布号 |
WO2013009525(A1) |
申请公布日期 |
2013.01.17 |
申请号 |
WO2012US45338 |
申请日期 |
2012.07.03 |
申请人 |
CELLECTIS S.A.;SILVA, GEORGE, H.;MACMASTER, RACHEL |
发明人 |
SILVA, GEORGE, H.;MACMASTER, RACHEL |
分类号 |
C12N9/22;C12N15/82 |
主分类号 |
C12N9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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