发明名称 |
SUSPENSION FORMULATIONS OF INSULINOTROPIC PEPTIDES AND USES THEREOF |
摘要 |
A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide, wherein the peptide is dispersed in the vehicle. The particle formulation further includes a stabilizing component comprising one or more stabilizers, for example, carbohydrates, antioxidants, amino acids, and buffers. Devices for delivering the suspension formulations and methods of use are also described. |
申请公布号 |
EP2157967(B1) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20080743213 |
申请日期 |
2008.04.22 |
申请人 |
INTARCIA THERAPEUTICS, INC |
发明人 |
ALESSI, THOMAS, R.;MERCER, RYAN, D.;ROHLOFF, CATHERINE, M.;YANG, BING |
分类号 |
A61K9/10;A61K9/00;A61K9/16;A61K9/70;A61K38/26;A61K47/14;C07K7/06;C07K14/605 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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