| 摘要 |
<p>The disclosure relates to internalising modular antibody based on one or more immunoglobulin domains, which comprises at least one binding structure located within the N-terminal portion of a domain, and comprises at least one binding structure acting as a binding site located within the non-CDR region of a domain, wherein
a) a first binding structure has a specificity to bind an extra-cellular portion of a receptor on a tumor cell, and
b) a second binding structure has a specificity to bind a soluble tumor associated antigen (sTAG), and an Fc fragment of an immunoglobulin, which binds to an EGFR epitope.</p> |
